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6.2 Concluding remarks and future directions In conclusion, this review has systematically traced SFNs journey from its biosynthetic origins in plants to its multifaceted mechanisms of action in human cancer prevention and therapy, ultimately addressing the translational challenges that currently limit its clinical application
By activating transcription factors like NF-B and activator protein 1 (AP-1) and upregulating kinases like phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinases (MAPKs), ROS generation can cause pro-inflammatory responses (Chen and Kunsch 2004)
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A review published in the Scientific World Journal shows that glutathione helps with elimination of fat-soluble compounds, especially heavy metals like mercury and lead
Dyslipidemia has also been studied in AIA mice and rabbits (59)